Chicago’s Leading Biotech Startups Revolutionizing Healthcare in 2023

Located in the heart of the Midwest, Chicago, Illinois is home to some of the most innovative and exciting startups in biotechnology. This bustling urban jungle is more than just the Windy City; it’s an entrepreneurial powerhouse, brimming with creativity and ground-breaking research within the Biotech industry. The following startups are renowned for their dynamic solutions and commitment to revolutionizing healthcare, life sciences, and other related industries through their unique products and services.

Vanqua Bio

Vanqua Bio is a visionary player in the biotechnology industry (, focusing on medical advancements to combat neurodegenerative diseases. The company was founded by James Sullivan and works well in the intersection of Biotechnology, Health Care, and Medical sectors to provide next-generation solutions for patients.

Surmount Bio

Surmount Bio is a stealth health care company based in Chicago, Illinois. The company is making great strides in the Biotechnology and Health Care industries. Unfortunately, the company has not yet provided a website, but it’s definitely a company to keep on the radar as it grows.

Amphix Bio

Amphix Bio ( offers bio-inspired materials for regenerative medicine. Operating in the Biotechnology, Nanotechnology, and Product Research industries, Amphix Bio is making valuable contributions with its innovative products.


Evozyne (, founded by Andrew Ferguson, Jeff Aronin, and Rama Ranganathan, is a biotechnology company specializing in protein design and molecular scale. Evozyne shows promise in redefining the Life Science and Medical industries with their distinct services.

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The Collaboratory

The Collaboratory ( spearheaded by Nick Lilovich, Rafael Jardim, and Sruti Balakrishnan, is a B2B SaaS company that leverages Artificial Intelligence to build document discovery tools for biopharma companies. The company’s effective use of Biotechnology, Machine Learning, SaaS, and Software technology has positioned it as a standout contender in the field.

Grove Biopharma

Founded by Geoff Duyk and Paul Bertin, Grove Biopharma ( uses materials science to offer solutions to peptide therapeutic challenges, thus revolutionizing the Biotechnology, Medical, and Therapeutics sectors.


Xentria ( is a biotech company focusing on developing novel therapeutics to address unmet clinical needs. The company operates in the Biopharma and Biotechnology industries and has proven to be a game changer with their novel therapeutics approach.

Avivo BioOptics

Avivo BioOptics ( offers cancer screening, optical biopsy, and risk stratification services. With its stronghold in the Biotechnology, Health Care, Manufacturing, Medical, and Medical Device industries, this medical equipment manufacturing company is making commendable advancements.

Fulton Labs

Fulton Labs ( operates as a health sciences campus in the heart of Chicago, making strides in the Biotechnology, Information Services, and Life Science fields.

Aqua Cultured Foods

AquaCultured Foods (, founded by Anne Palermo and Brittany Chibe, is a fascinating startup operating in the AgTech, Biotechnology, and Food Processing sectors. They’ve attracted attention with their alternative seafood option, created through microbial fermentation.

Hyfé Foods

Hyfé Foods (, founded by Andrea Schoen and Michelle Ruiz, is unique in its approach, using fungal fermentation to produce ingredients and upcycle water by-products from food manufacturers. Their groundbreaking work sees them operate in Biotechnology, Food and Beverage, and Manufacturing industries.

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Clever Carnivore

Venturing into the Food and Beverage sector, the Clever Carnivore ( startup is developing cell-cultured meat inspired by Biotechnology.

Opera Bioscience

Opera Bioscience ( ensures researchers have access to high-quality and affordable reagents and material proteins, making a substantial impact in the Biotechnology and Product Research fields.


BiopharmIQ (, a creation of Dominic Vacchiano and Emanuel Vacchiano, is setting a high bar in the Biopharma, Biotechnology, and Clinical Trials sectors. The company provides clinical trial catalyst & pipeline information for public smidcap biopharma companies, offering valuable and insightful services.

AddGraft Therapeutics

AddGraft Therapeutics ( is taking revolutionary strides in the Biotechnology and Health Care fields by developing a gene delivery platform that can cure substance abuse disorder through a one-time treatment.

All of these innovative Chicago-based startups are disrupting the traditional norms of Biotechnology by providing groundbreaking solutions. It can be firmly stated that the Windy City is indeed a fertile breeding ground for budding BioTech businesses.

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